Abstract
Zika virus (ZIKV) infection is an emerging global health concern, and diagnostic recommendations are currently developing based on new information. Several case or small sample size studies using both urine and blood samples suggest that ZIKV RNA can be detected at higher levels and for a longer time after onset of infection in urine compared to blood. We recommend that urine and serum collection for molecular testing be a standard part of evaluating patients for ZIKV infection, and that urine is a good alternative testing sample when blood collection is problematic.
Keywords: Molecular diagnostic; Urine biomarker; Zika infection; Zika virus.
Similar articles
-
Urine-based molecular diagnosis of Zika virus.Int Urol Nephrol. 2016 Dec;48(12):2023. doi: 10.1007/s11255-016-1417-6. Epub 2016 Sep 20.PMID: 27650447 No abstract available.
-
Detection of Zika virus in urine.Emerg Infect Dis. 2015 Jan;21(1):84-6. doi: 10.3201/eid2101.140894.PMID: 25530324 Free PMC article.
-
Reply to the letter: Urine based molecular diagnosis of Zika virus by Viroj Wiwanitkit.Int Urol Nephrol. 2016 Dec;48(12):2025. doi: 10.1007/s11255-016-1424-7.PMID: 27687554 No abstract available.
-
Zika Virus.Clin Microbiol Rev. 2016 Jul;29(3):487-524. doi: 10.1128/CMR.00072-15.PMID: 27029595 Free PMC article. Review.
-
Laboratory Diagnosis of Zika Virus Infection.Arch Pathol Lab Med. 2017 Jan;141(1):60-67. doi: 10.5858/arpa.2016-0406-SA. Epub 2016 Oct 20.PMID: 27763787 Review.
Cited by
-
Non-Invasive versus Invasive Samples for Zika Virus Surveillance: A Comparative Study in New Caledonia and French Guiana in 2015-2016.Microorganisms. 2021 Jun 16;9(6):1312. doi: 10.3390/microorganisms9061312.PMID: 34208593 Free PMC article.
-
Zika Virus Outbreak on Curaçao and Bonaire, a Report Based on Laboratory Diagnostics Data.Front Public Health. 2019 Nov 12;7:333. doi: 10.3389/fpubh.2019.00333. eCollection 2019.PMID: 31781532 Free PMC article.
-
Highly Sensitive and Selective Direct Detection of Zika Virus Particles in Human Bodily Fluids for Accurate Early Diagnosis of Infection.ACS Omega. 2019 Apr 30;4(4):6808-6818. doi: 10.1021/acsomega.9b00374. Epub 2019 Apr 15.PMID: 31058250 Free PMC article.
-
Rapid Detection of Zika Virus in Urine Samples and Infected Mosquitos by Reverse Transcription-Loop-Mediated Isothermal Amplification.Sci Rep. 2018 Feb 28;8(1):3803. doi: 10.1038/s41598-018-22102-5.PMID: 29491389 Free PMC article.
-
Advances in Diagnosis, Surveillance, and Monitoring of Zika Virus: An Update.Front Microbiol. 2018 Jan 19;8:2677. doi: 10.3389/fmicb.2017.02677. eCollection 2017.PMID: 29403448 Free PMC article. Review.
